Liverpool have been on a rocky patch since returning from the Premier League's winter break, with Atletico Madrid beginning the rot with a 1-0 three weeks ago.
As for Atletico, they only have two victories in their last five La Liga matches, scrapping for a top four place.
Can they roll their sleeves up and get the job done at Anfield?
Liverpool predicted lineup
MISSING MAN - Goalkeeper Alisson is now set to miss out
Liverpool injury news
Andrew Robertson (knock) was rested against Bournemouth but should return for this vital Champions League clash.
There are no other fresh injuries, but Xherdan Shaqiri (calf) and Nathaniel Clyne (knee) are still short of fitness.
Jurgen Klopp is set to go with the same team that saw off Bournemouth 2-1, with Robertson returning at left back in the place of James Milner.
Atletico Madrid predicted lineup
CLEAN HEALTH - Atletico have had their injury troubles ease since the first leg
Atletico Madrid injury news
Given Atletico were missing Kieran Trippier and Joao Felix for the first leg, and Diego Costa was only fit enough for the bench, Diego Simeone's men are going into the return fixture with a much healthier squad.
Thomas Lemar (thigh) is yet to recover from his injury from the first tie, but Simeone has the rest of his squad at his disposal.
Felix and Alvaro Morata both scored in the 2-2 draw against Sevilla at the weekend, so expect them to lead the line for Los Rojibancos.
Date: Wednesday, 11 March 2020
Kick-off time: 3pm ET / 8pm GMT
Location: Anfield, Liverpool (Liverpool)
Referee: Danny Makkelie (Netherlands)
On TV: BT Sport 2 (UK), TNT (USA)