The Champions League Round of 16 is well underway, but the biggest clash comes between Real Madrid and Manchester City.
Los Blancos will still be focusing on the league, having just let their lead in La Liga slip, and face Barcelona this coming weekend.
As for City, with the league title already forfeited to Liverpool and a two-year European ban looming - this season's Champions League is EVERYTHING.
Real Madrid lineup
UNGALACTICO - The Real side isn't looking as strong as previous seasons
(Eden Hazard is now injured - Isco likely replacement)
Real Madrid injury news
The big miss for Real Madrid is summer signing from Chelsea, Eden Hazard (ankle), who is likely to be out for the rest of the season.
Mariano Diaz (knock) remains out, whilst the City clash is set to come a game too soon for Marco Asensio (knee).
Manchester City lineup
ALL OR NOTHING - Will this City side pick up a historic win in Madrid?
Manchester City injury news
Leroy Sane (knee) is on the only injury problem for Pep Guardiola, but the German is expected to return in the coming weeks.
Long-term absence Aymeric Laporte (knee) has recently come through starts against Sheffield United, West Ham and Leicester, but did not play the 90 minutes in any of those ties.
Other question marks come on the flanks with Guardiola having to choose between Bernardo Silva or Riyadh Mahrez on the right-hand side.
Date: Wednesday, 26 February 2020
Kick-off time: 3pm ET / 8pm GMT
Location: Santiago Bernabeu, Madrid (Real Madrid)
Referee: Daniele Orsato (Italy)
On TV: BT Sport (UK), TNT (USA)