The winner of the semi-final will return under the arch next month for the final showpiece against the victor of the heavy-duty clash between Chelsea and Manchester City.
Latest - Predicted Lineups
It's the Foxes against the Saints in an all-out battle at Wembley Stadium!
Leicester Predicted 11
Trio James Maddison, Ayoze Perez and Hamza Choudhury should all be able to return for Rodgers following their club ban for breaching Covid-19 protocols.
Cengiz Under, James Justin and Harvey Barnes are all ruled out by injury for the Champions League chasers, although Caglar Soyuncu might be fit to return following his illness.
Southampton Predicted 11
The Saints will be without Takumi Minamino, who is cup-tied having featured for Liverpool earlier in the competition.
Michael Obafemi will also be absent from the front line, with Will Smallbone and Oriol Romeu also not fit to take part.
How to watch Leicester vs Southampton
Both FA Cup semi-finals will be shown live on BBC One, which is available to all viewers in the UK.
The game will also be streamed on BBC iPlayer and online, with various commentary options.
BBC Leicester vs Saints Schedule
Emirates FA Cup Semi-Final - Coverage to start from 5:30pm on Sunday, 18 April (BBC One)
All times UK
How to watch FA Cup Semi-Finals in the USA
FA Cup matches can be seen exclusively on ESPN+ in the US.
Both semi-finals will be streamed live in English and Spanish.
ESPN+ will also provide highlights and analysis of FA Cup games throughout the weekend on its "ESPN FC" show, including a special recap edition on Sunday, 18 April.
An ESPN+ subscription will cost you $5.99 per month or $59.99 annually.
It can also be bundled in with Disney+ and Hulu for $12.99 per month, or you can choose to remove the ads on Hulu for $18.99 per month.
Leicester City vs Southampton FC FA Cup Semi-Final Date
Both of this season's FA Cup semi-finals will be held at Wembley Stadium and will go to extra-time and penalties if the scores are level after 90 minutes and extra time.
The FA Cup semi-final between Leicester City vs Southampton FC will take place on Sunday, 18 April, with the action set to kick-off at 6:30pm BST / 1:30pm EST.
FA Cup semi-final match officials and VAR confirmed
Referee Chris Kavanagh has been selected to take charge of the Leicester vs Southampton tie.
The two assistant referees running the lines will be Dan Cook and Sian Massey-Ellis.
David Coote has been named as the fourth official, with Nick Hopton the reserve assistant.
VAR (video assistant referee) will be Paul Tierney, assisted by Adam Nunn.
4,000 locals allowed in stadium for FA Cup Semi-Final
Spectators will be returning to Wembley for the FA Cup semi-final between Leicester and Southampton with 4,000 local residents allowed to attend the game.
The match is being run as a test event for the return of crowds once coronavirus lockdown restrictions are eased, but neither Leicester nor Southampton are permitted their own supporters at the game.
Fans have been prevented from attending sports venues across England since the scrapping of the tier system in December, so this is a big breakthrough for the football community!