Reading will look to recover their EFL Championship form when they travel to Kenilworth Road on Tuesday night.
RealSport101's Harry Smith is on hand to provide a comprehensive preview of Saturday's EFL Championship battle, including team news, predicted starting XIs and predictions.
Luton vs Reading Team News
Luton boss Nathan Jones could shuffle his starting XI around on Tuesday night with Pelly-Ruddock Mpanzu set to replace the injured Henri Lansbury in central midfield.
Gabriel Osho will miss out on the opportunity to face the club that raised him as an academy graduate as he serves the second instalment of a three-match suspension.
Reading will stick with the 3-4-2-1 system deployed against Burnley on Saturday afternoon but could recall targetman Andy Carroll with Ovie Ejaria the man most likely to make way.
Mamadou Loum is suspended after receiving his fifth yellow card of the season at Turf Moor. Nottingham Forest loanee Tyrese Fornah looks like a sure bet to take his place at the base of the Reading midfield.
Centre-back Tom McIntyre is also out of Tuesday night's trip to Kenilworth Road after picking up an injury over the weekend, so expect Junior Hoilett to start out wide with Amadou Mbengue slotting into the back three.
Luton: Reece Burke, James Shea, Henri Lansbury (doubtful), Gabriel Osho (suspension)
Reading: Naby Sarr, Liam Moore, Scott Dann, Femi Azeez, Tom McIntyre, Sam Hutchinson (doubtful), Mamadou Loum N'Diaye (suspension)
Luton (3-5-2): Horvath; Bree, Lockyer, Potts; Doughty, Clark, Mpanzu, Campbell, Bell; Morris, Adebayo
Reading (3-4-2-1): Lumley; Mbengue, Holmes, Yiadom; Hoilett, Fornah, Hendrick, Rahman; Meite, Ince; Carroll
Luton vs Reading Score Prediction
Luton's charge up the table has lost steam over the past couple of weeks with the Hatters following up a 4-0 derby day defeat against Watford with an uninspiring 1-1 draw with Sunderland on Saturday.
Nathan Jones' men have still lost just one of their last nine league games though and will hope that the attacking threat of Carlton Morris and Elijah Adebayo can cause problems for a makeshift Reading backline.
Reading's rapid start to the 2022/23 EFL Championship season feels like a distant memory with the Berkshire side suffering their fourth defeat in the space of five games at Turf Moor on Saturday.
Paul Ince was furious with the officials in the wake of the defeat to Burnley and will hope to galvanise a Reading side that has lost each of their last three league games away from the Select Car Leasing Stadium.
Score Prediction: Luton 2-1 Reading
Harry Smith's Tip: BTTS - Yes