Host nation Russia and Saudi Arabia will look to get the 2018 World Cup off to a flying start in Thursday evening's opener, while Egypt and Uruguay will have to wait until Friday afternoon to get their campaigns underway.
Uruguay will be the favourites to emerge from the group, given their superior experience and notable firepower up front, but the other three sides will keep a close eye on the runners-up spot.
Read RealSport's Egypt vs Uruguay preview HERE.
The big news ahead of this game, though, is that Mo Salah will indeed be fit to start against the Uruguayans, handing the Pharaohs a much-needed boost.
The first fixture of a World Cup is a big occasion for every player involved, and for the fans back home. Here are a few things we can look forward to in this second match of Group A...