These are the ties to watch out for in the early season.
Here's the warning - you have until Friday, 13 August at 6:30pm BST to create and tinker with your side.
The honour of opening the campaign goes to Premier League new boys Brentford, who host Arsenal - with many tipping an early season upset for the Bees.
Brentford vs Arsenal
Burnley vs Brighton
Chelsea vs Crystal Palace
Everton vs Southampton
Leicester City vs Wolverhampton
Manchester United vs Leeds United
Newcastle United vs West Ham United
Norwich City vs Liverpool
Tottenham Hotspur vs Manchester City
Watford vs Aston Villa
Liverpool perhaps have the easiest run to begin with for the new campaign.
The Reds commence the season with Norwich (A), Burnley (H), Chelsea (H), Leeds (A), Crystal Palace (H) and Brentford (A) - where would you expect them to pick up four or five wins in opening six fixtures.
Therefore you should line up stars such as Mohamed Salah (£12.5m) and Trent Alexander-Arnold (£7.5m) to give your team some real firepower.
We know the usual suspects when it comes to FPL, but they are never cheap.
The top three players from the 2020/21 season will be up there once again with Bruno Fernandes (£12.0m), Harry Kane (£12.5m), and Mohamed Salah (£12.5m) all players we will look to include from the start.
Heung-Min Son (£10.0m) and Jamie Vardy (£10.5m) are two other big hitters that will guarantee you points throughout the season too.
Defensively Manchester City were brilliant last season, so the likes of Ederson (£6.0m), Ruben Dias (£6.0m), and Joao Cancelo (£6.0m) should all be in your thoughts.
Every year there are some surprise stars that offer fantastic value for money.
Leeds stars Stuart Dallas (£5.5m) and Patrick Bamford (£8.0m) were our two favourites last season, with Sheffield United’s John Lundstram the main man in 2019/20.
Leeds’ double act are unlikely to be as cheap next season, and Dallas will likely be shifted into a midfield role too!
With the prices yet to be confirmed it is difficult to predict the bargain buys but be on the lookout for defenders who will play regularly in a more advanced role.
Bruno Fernandes (£12.0m) looks like an early contender for the armband in the early season fixtures.
Manchester United play Leeds, Southampton, and Wolves in their opening three games of the season, so maximum points certainly look possible.
The Portuguese magician is almost guaranteed to play in each of those games too, so make a note of him when you are selecting your teams.
Mohamed Salah (£12.5m) is another option too as Liverpool has a favourable opening two matches against Norwich and Burnley.
After selling Emiliano Buendia (£6.5m), Norwich’s transfer window has become increasingly important to their chances of survival.
The Canaries face Liverpool, Manchester City, and Leicester in their opening three matches and follow it up with a trip to Arsenal.
With such a tough start, we would avoid selecting any Norwich players in the early stages of the season.
It will be a baptism of fire back in the Premier League, but any points picked up will be priceless.