They will be hoping to retain their Premier League crown, with summer signing Jack Grealish the only noticable enforcement over the summer.
City's team have had some major upgrades on FIFA 22, so check out their ratings below.
Latest - Great away week
Manchester City have just encountered one of the toughest weeks you could imagine in world football.
They excelled at Chelsea, stamping down a marker with a win against the team most people think will be their closest title challengers.
A loss to PSG was disappointing, but the performance was decent again, and it shouldn't have too much impact on getting out of the group in the Champions League.
The most exciting game was against Liverpool, with City twice coming from behind to earn a 2-2 draw.
Phil Foden and Mohamed Salah both excelled, with a potential TOTW coming in Ultimate Team.
Kevin De Bruyne (OVR 91)
Injury once again blighted Kevin De Bruyne's season, but he still showed that he is one of the world's best in his limited game time.
KDB is the joint best player - with Cristiano Ronaldo - in the Premier League in FIFA 22 and will be the main man for Man City once more.
Ederson (OVR 89)
Last season's Golden Glove winner, Ederson's rating increased for FIFA 22.
The Brazilian is one of the best GKs on the game and his distribution is second to none.
Raheem Sterling (OVR 88)
England winger Raheem Sterling found himself out of favour towards the end of last season and still isn't the first choice pick this term.
There is no doubting Sterling's quality, but if he is not starting week in week out it will be hard to maintain an 88 OVR.
Great form at Euro 2020 has seen him keep the rating for now, but don't be surprised if this drops in updates throughout the season.
Ruben Dias (OVR 87)
Ruben Dias saw a massive +6 increase to his rating for FIFA 22.
No one can argue it wasn't deserved, with his impact on City's defence comparable to Virgil van Dijk's arrival at Liverpool.
He is now up there with the best defenders on the game, with the highest rating being an 89 OVR.
Joao Cancelo (OVR 86)
We saw the best of Joao Cancelo last season and Man City fans will be hoping he can replicate his terrific mid-season form.
The Portuguese international was desperately unlucky to miss Euro 2020, but that just made him fresh and raring to go for the new season.
Riyad Mahrez (OVR 86)
A bit of a surprising upgrade here, as the nine Premier League goals last campaign are not enough for a player of his quality.
Yet not many players possess the ability that Riyad Mahrez does, which makes his inconsistency all the more frustrating.
He put in some great performances at the end of last season, which was probably in developers minds when they gave him the increase.
Bernardo Silva (OVR 86)
Bernardo Silva scored just two Premier League goals last season, so a downgrade was almost inevitable.
As predicted, we are seeing Silva in central midfield this season, and he has been fantastic.
There is a lot of talk that he is wanting out of the club, which would be an incredible loss for City.
Aymeric Laporte (OVR 86)
We couldn't see how Aymeric Laporte was going to force his way back into the starting XI.
He hadn't done anything wrong, but the form of Ruben Dias and John Stones was incredible.
He has been starting ahead of Stones at the start of this season, due to a lack of pre-season for Stones, and now the tables have turned, with Stone's needing to break up another formidable partnership.
Rodri (OVR 86)
Spanish midfield general Rodri looks to have adapted well to the Premier League.
His physique makes him well-suited to the fast-paced and physical style of the Premier League, and last season he looked much more assured in the middle of the park.
Ilkay Gunodgan (OVR 85)
German midfielder Ilkay Gundogan enjoyed a sensational season in 2020/21.
With 17 goals in all competitions, Gundogan provided an extra threat when KDB was out injured.
Gundogan also picked up a handful of individual awards too, seeing his rating increase in FIFA 22.