So, here are all the latest details on the UCL match-up between the Premier League leaders and the German giants.
Man City vs Borussia Dortmund Date & Kick-Off Time
All four of the quarter-final matches will be played over two legs, with each team playing one leg at home.
The first leg between Man City and Dortmund will take place at the Etihad Stadium on Tuesday, 6 April at 3pm ET / 8pm BST.
The return leg will be played at Signal Iduna Park on Wednesday, 14 April, which will also be a 3pm ET / 8pm BST kick-off.
Whichever side makes it through to the semi-finals will play either Bayern Munich or PSG on Tuesday, 27 April / Wednesday, 28 April, with the second leg set to take place on Tuesday, 4 / Wednesday, 5 May.
How to watch Man City vs Dortmund
If you are watching from the UK, BT Sport is the place to catch all the Champions League games.
With exclusive matches all the way to the final, you’ll be able to watch on TV, online and on the BT Sport app for mobiles, tablets, smart TVs and games consoles.
You can purchase a Monthly Pass which gets you 30 days of BT Sport, contract-free.
BT Sport Man City vs Dortmund Schedule
UEFA Champions League Quarter-Final 1st Leg - From 7pm on Tuesday, 6th April (BT Sport 3 / BT Sport Ultimate)
UEFA Champions League Quarter-Final 2nd Leg - From 7pm on Wednesday, 14th April (BT Sport 3)
All times UK.
How to watch UCL in the USA
In the USA, all Champions League matches are available live on CBS All Access, which is the network's online streaming service.
A select few, including the Champions League Final, will be shown on TV via CBS Sports Network.
Borussia Dortmund head into the quarter-final tie with some key squad members injured, while Pep Guardiola has a fully-fit group of players at his disposal.
Manchester City Predicted 11
We are expecting to see Man City use a back four of Kyle Walker, John Stones, Ruben Dias and Joao Cancelo on the left side - with the creativity and control in the centre of the park which he brings.
In midfield, we would be very surprised if Gundogan didn't return to the starting 11, along with Rodri and Bernardo Silva.
Guardiola will choose from Sterling, Mahrez and Foden to occupy the wide areas, with Belgian magician Kevin De Bruyne operating in the false 9 position.
Borussia Dortmund Predicted 11
Jadon Sancho will be denied his Manchester City reunion, as he is still recovering from a muscle injury picked up before the international break.
With trusted midfielder Witsel still on the road to recovery after suffering a torn achilles tendon in January, teenager Jude Bellingham is likely to retain his central midfield berth, presenting England fans the chance to see the Brummie in action ahead of Euro 2020.
Out: Jadon Sancho (muscle), Axel Witsel (achilles), Dan-Axel Zagadou (knee), Marcel Schmelzer (knee), Youssoufa Moukoko (ligament), Mahmoud Dahoud (suspension)
City scored three goals in each of their first three Group C victories this season, beating Porto (3-1), Marseille and Olympiacos (both 3-0) before a 1-0 win in Greece on Matchday 4 secured progress.
A 2-0 win against Leicester City in their last outing increased Man City's lead at the top of the Premier League.
Last six games: WWWWWL
Latest outing: Manchester City 2-0 Leicester City, 03/04
Borussia Dortmund currently sit fifth in the Bundesliga, having lost 2-1 to Eintracht Frankfurt in their previous outing.
Mixed results have been at the heart of an unsettled period for Dortmund, but they could turn things around in the Champions League!
Last six games: LDWDLW
Latest outing: Borussia Dortmund 1-2 Eintracht Frankfurt, 03/04
With only one win to boast from their last five matches, compared to City's perfect record in that period, Dortmund are not exactly high on confidence.
Haaland is always capable of popping up with a crucial goal for the Black and Yellow, but a fully-fit and in-form City can sweep aside almost anything in their path, so we can only back a first leg triumph for Guardiola's men.
Manchester City 3-1 Borussia Dortmund