Swansea are a new-look side after selling Fernando Llorente and Gylfi Sigurdsson, impressively replacing them with former striker Wilfried Bony and the shock loan signing of Bayern Munich midfielder Renato Sanches.
For Newcastle, meanwhile, the pressure is on Rafael Benitez after two defeats in their opening three games, though the 3-0 victory over West Ham was a markedly improved performance.
RealSport have selected three key tactical and personnel changes that could influence the game.
1 A loss of goals
Swansea largely stayed up last season thanks to the goals of Gylfi Sigurdsson and Fernando Llorente, however having lost both this window, you would be forgiven for wondering where the goals will come from.
Tammy Abraham has made a good start to life on loan at the Swans and is an exciting talent. Opening his Premier League account in their last outing against Crystal Palace was crucial and he can replace the goals Llorente provided.
Add that to the return of former hero Wilfried Bony and the Welsh side suddenly have a rather potent strike force.
However, the goals and assists Sigurdsson provided will be difficult to replace.
Goal-scoring midfielders are a rarity in the game and other players will have to step up to provide a better output now the Icelandic international is gone.
All eyes will be on how Renato Sanches performs.
2 Newcastle's change in style
Having lost their opening two games on their return to the Premier League, with not much to shout about, it was crucial Newcastle got all three points against West Ham in their last fixture.
The Magpies ended up as 3-0 winners and were far more inspiring, with Newcastle excellently pressing West Ham into making mistakes on the ball. Their first and third goals were, in fact, a direct result of this pressing.
Rafael Benitez usually sets his side up in compact, low block shapes with a solid defensive structure, so the fact he was looking to press the ball far more aggressively is surprising, and no doubt a relief for their fans.
Swansea are a possession-based side who like to keep the ball on the floor and take risks on the ball.
However, it can lead them into becoming the victims of organised pressing, so it will be interesting to see if Benitez sets his side out with similar instructions in Wales.
3 Consistent crossing
No player scored more headed goals (7) than Llorente for Swansea last season. He may have left the club, but both Abraham and Bony are sizeable presences who are a threat in the air.
It means Paul Clement is likely to instruct his side to pump the box with crosses from wide areas either to get headers on targets or create second ball situations for the likes of Sanches to exploit.
Benitez also likes to get the ball out wide, largely due to his lack of a true playmaker, instead utilising Ayoze Perez as more of a second striker.
However, without the focal point of Aleksandar Mitrovic to plant crosses onto, Newcastle may be forced to rely on set pieces to provide their best chances.
Both sides will need to be organised when dealing with balls into the box as both provide a threat in the air.
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