The Manchester City striker will be leaving the club at the end of the season, so we could see an End of an Era card to celebrate the Argentine's achievements.
Check out our concept card and predictions below.
The FUT Birthday event has rejuvenated Ultimate Team on FIFA 21 after we went two weeks without a proper event.
So far we have had a great new SBC card released every day, and FUT Birthday Team 1 is currently available in packs.
End of an Era
EA has celebrated players moving on already this season with three End of an Era cards already released.
The first was a huge 93 OVR Wayne Rooney. The England legend transitioned into management this season, and we think he could become a FIFA 22 Icon.
The most recent End of an Era cards were released at the same time, with Bayer Leverkusen's Bender twins offering great value cards.
See how to unlock Sven and Lars Bender here as there is still time to complete the SBC before it expires on Saturday, 3 April.
Sergio Aguero will certainly go down as one of the greatest strikers in Premier League history, so we expect his departure from Manchester City to be acknowledged by EA.
An End of an Era card seems most fitting, and it is bound to be rated at least 90 OVR or higher in line with some of the other special cards we have seen this season.
There have been so many memorable Aguero moments, but his stoppage-time winner against QPR to seal the title for City will go down as one of the most iconic goals of all time.
Any special card for Aguero will certainly be quick and great at finishing, so it will likely come at a hefty price too.